Naavudi Reviewed: Diabetes Supplements – Do They Work?
Naavudi is a dietary supplement made from natural (organic plants) ingredients that have been specially formulated to provide glucose support.
In this in depth review we will look at exactly how Naavudi works, the ingredients it contains and the kind of results you can expect.
We will also look at whether there have been any known side effects, and the best way to take the supplements as part of your everyday diet.
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Naavudi Reviewed -- A Vault50 Analysis
Dietary Conditions of the Modern World
Modern lifestyle has been occasioned by diet changes, and this has impacted the health status of modern people.
One of the key health outcome of the changing diet patterns and sedentary lifestyle has been the upsurge in diagnosis of non-communicable ailments or diseases.
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There are different types of non-communicable diseases (NCDs), and they are divided into disease groups, with one of the major groups being metabolic disorders.
Metabolic disorders are conditions caused by derangements in the normal metabolic processes that are primarily caused by altered or non-equilibrated biochemical reactions in the body which disrupt normal homeostasis, and consequently cause a physiological disequilibrium in the body.
One of the ways of managing metabolic disorders is by taking dietary supplements.
Naavudi is a dietary supplements specially formulated to manage disorders of carbohydrate metabolism, specifically type II diabetes mellitus.
To understand how Naavudi works as a Glucose Support supplement, there is need to understand what disorders of carbohydrate metabolism are; and specifically how diabetes mellitus develops.
Disorders of Carbohydrate Metabolism
Metabolic processes are the mainstay of metabolism, as they determine how the food consumed by a person is digested, absorbed, and assimilated by the body, or metabolized by cells to produce life-sustaining energy.
This processes allows food protein to be broken down in the digestive tract into small units (poly-peptides, peptides, and amino acids) that can be absorbed through the intestinal wall into the blood circulation.
It is then delivered to different body organs where it is converted through catabolic and anabolic biochemical processes into amino acids.
These in turn can be assimilated (integrated) into muscle protein hence causing an increase in bodily muscle mass.
However, protein metabolism requires energy, and this energy is provided by either fat metabolism or glucose metabolism.
Fat also undergoes metabolic processes which allow them to be metabolized as energy sources as well as be stored in adipose tissue if the body has enough energy.
However, the body prefers to derive its energy from glucose metabolism rather than fat metabolism, as glucose can be easily and quickly metabolized by the body as compared to fat.
This means that glucose metabolism is the mainstay of energy-producing metabolic processes.
A short word on Carbs
Carbohydrates from consumed foods provide the substrates of glucose metabolism. Generally, the complex carbohydrate in food (especially starch) is broken down through a process called carbohydrate catabolism into small units called polysaccharides or even smaller units called oligosaccharides.
The 3 common disaccharides
These disaccharides are then broken down into their constituents monosaccharide units as follows: lactose yields galactose and glucose; sucrose yields fructose and glucose; and maltose yields glucose and glucose.
There are therefore 3 main monosaccharides that the body metabolizes; glucose, fructose, and galactose.
Monosaccharides are also called simple sugars. Glucose is transported by blood which allows cells around the body to absorb it (from the blood) and then metabolize it to provide cellular energy.
Even so, the body cannot directly use galactose to produce energy, and this monosaccharide must undergo a biochemical conversion process that chemically breaks it down into a glucose metabolite, while fructose enters the glucose metabolic pathway after it has been phosphorylated.
This is because the body uses glucose as its primary metabolic fuel.
Why beer helps pile on the pounds
This also explains why beer drinking causes a person to gain weight as the maltose is quickly catabolized into 2 glucose units with minimal energy input as compared to lactose and sucrose;.
This allows the body to produce almost all its energy from maltose and thus store the other digested fat and carbohydrates as fat in adipose tissue, hence increasing the fat mass in the body, and if this increase is left unchecked, it causes obesity.
Obesity is a risk factor that precipitates a myriad of metabolic disorders, with one of the most debilitating metabolic disorders being diabetes mellitus (colloquially called diabetes).
Both are called diabetes because they cause excess production and excretion of urine (a medical condition referred to as polyuria), and diabetes is latin derivative of the late Greek word, diabetes, which means excessive urination (discharge of urine).
What is Diabetes Inispidus?
Diabetes inispidus is caused by either a hormonal disorder (lack or insufficient production of vasopressin [also called anti-diuretic hormone]) or kidney disorder (also called nephrogenic DI as it occurs because the kidneys cannot respond appropriately to vasopressin);
This is characterized by production of large amounts of dilute (normally sugar-free) urine. There are also 2 rare types of diabetes insipidus that are caused either by pregnancy (Gestational DI) and excess water intake (due to a damaged hypothalamus and/or pituitary gland).
What is diabetes mellitus?
Diabetes mellitus is a metabolic disorder characterized by high glucose concentration in the blood for prolonged period.
This leads to production of large amounts of glucose-containing urine, a condition called glycosuria.
This characterization takes into account time duration because the blood glucose concentration is bound to rise after one consumes meal because the digested meal provides lots of glucose that is absorbed across the intestines and into the bloodstream, and this normal physiological process is called Post-prandial Hyperglycemia.
However, this blood glucose concentration is bound to decrease as cells absorb glucose from the bloodstream and within hours the glucose concentration in blood (commonly called blood sugar concentration) is returns to normal.
How cells absorb glucose
Cells can only absorb glucose when the hormone insulin binds to the insulin receptor located on their cell membranes.
When insulin binds to its receptor, its activates a cellular cascade that allows an insulin-regulated glucose-transporter protein (called GLUT-4 transporter) to be inserted into the cell membrane.
GLUT-4 allows glucose to enter the cell through a passive transport process -- which does not require any energy input -- called facilitated diffusion.
This means that if insulin is not available, no GLUT-4 transporters will be inserted in the plasma membrane and therefore glucose in the bloodstream cannot enter the cell.
This is the basis of diabetes mellitus, as the high blood sugar concentration (including that caused by post-prandial hyperglycaemia) cannot fall down as glucose cannot be absorbed by cells
Because of this, the concentration in blood (biologically described as plasma concentration) remains high for a long time, while cells starve as they cannot get glucose to metabolize for their energy needs.
Therefore, diabetes mellitus causes a paradoxical conditions best described as cellular starvation in an environment full of glucose.
The 2 types of diabetes mellitus
There are 2 types of diabetes mellitus; Type I and Type II DM. Type I DM is caused by failure of the body to produce adequate amounts of insulin, and this condition is also called insulin-dependent diabetes mellitus (IDDM).
If exogenous insulin is injected into the body – a procedure called insulin therapy -- the symptoms of diabetes mellitus abate as the cells can absorb glucose from the blood.
The beta-cells located in the islets of Langerhans of the pancreas produce insulin, and if these cells are destroyed by an autoimmune reaction, then Type 1 DM results.
Type II DM is caused by insulin resistance, that is, insulin is available and it binds to its respective insulin receptor located in cell membranes but this binding does not activate the cellular cascade that cause the GLUT-4 transporters to be inserted in cell membranes, and without GLUT-4 transporters, glucose cannot be absorbed by cells.
For this reason it is called non insulin-dependent DM (NIDDM). Type II DM is commonly caused by obesity and a sedentary lifestyle, and because these develop during adulthood, Type II DM is also called adult-onset diabetes mellitus.
Managing Type I and Type II Diabetes
Type I DM can best be managed by insulin therapy, but Type II DM can be managed through lifestyle changes, dietary interventions, and anti-diabetic medications.
Regarding medications, use of anti-diabetic medications that have manufactured by pharmacies is called conventional therapy, and the major downside of this therapy is the adverse effects caused by these medications including skin rash, kidney complications, weight gain, and swollen ankles or legs.
Luckily, there is an alternative to anti-diabetic medications, and this alternative involves managing Type II DM using dietary supplements, and this form of therapy is described as alternative therapy.
Sometimes, dietary supplements can be used along with anti-diabetic medications and this form of therapy is called combined medication.
Even so, there is a highly effective dietary supplement that can efficaciously manage Type II DM, and this product is called Naavudi.
What is Naavudi?
Naavudi is a dietary supplement made from natural (organic plants) ingredients that have been specially formulated to provide glucose support.
It is described as a glucose support nutrient/dietary supplement because it promotes the digestion and absorption of glucose into the bloodstream, as well as promotes glucose intake into the cells by increasing the sensitivity of these cells to insulin.
Ultimately, it not only optimizes the digestion process along with carbohydrate metabolism, but it also ensures that the blood sugar concentration is maintained within normal range by ensuring that cells take in adequate amounts of glucose which can provide enough energy to support their cellular metabolism.
Because this dietary supplement works primarily by increasing insulin sensitivity in cells, it predominantly manages NIDDM or Type II diabetes mellitus.
However, Naavudi can be used to manage very mild forms of Type I DM or IDDM.
Pathophysiology of Type II Diabetes Mellitus
To understand how Naavudi works at the cellular-physiological level to manage Type II DM by providing glucose support, there is a need to understand how the NIDDM develops into a metabolic disorder and its systemic effects on vital body organs including the kidneys, eyes, and brain.
What is NIDDM?
NIDDM is a chronic condition caused by insulin resistance. This resistance predominantly affects in cells located in liver, fat, and muscle tissues.
When liver cells (also called hepatic cells) cannot absorb enough glucose from the bloodstream, they automatically interpret this as lack of sufficient glucose in the blood, and they signal the liver to release stored glucose as well as glucose derived from breakdown of non-carbohydrate substrates, into the bloodstream.
This in turn causes the blood sugar level, which was high to start with, to increase even further; and if the liver continues to release more glucose into the blood, the osmotic concentration of glucose in the bloodstream rises so high (sometimes above 320milliosmoles-per-kg [mOsm/kg] ) that the blood pH rises to above 7.3 in a state called Hyper-osmolar hyper-glycemic state (HHS).
In such circumstances, the affected person falls into coma – a condition called Hyperosmolar non-ketotic coma (abbreviated as HONK) or Hyper-osmolar hyper-glycemic non-ketotic coma (abbreviated HHNC).
The impact of cellular starvation in fat tissue
Meanwhile, in the fat tissue, cellular starvation leads to breakdown of fat cells to produce fatty acids and glycerol that are destined to be transported to the liver where they can be converted into glucose through a process called gluconeogenesis.
The fatty acids are initially metabolized into acidic ketone bodies which are then released into the bloodstream to be transported to the liver.
If large amounts of these ketone bodies are released into the bloodstream, a life-threatening condition called diabetic ketoacidosis (DKA) occurs in which the affected person feels weak, confused, requires deep gasping breathes (a breathing pattern called Kussmaul respiration), vomits a lot, experiences abdominal distention along with abdominal pain; and may well even lose consciousness.
If these ketone bodies are transported by blood into the brain, the subsequent DKA causes brains cells to be filled with fluids, as fluids accumulate in the spaces between the brain cells; and this life-threatening condition is called cerebral edema.
Cerebral edema can cause the affected person to fall into a form of coma known as diabetic coma.
In the muscles, glucose is stored as glycogen (the liver also stores glucose as glycogen). During periods of cellular starvation, muscle cells trigger the muscle tissue to breakdown glycogen to release glucose through a process called glycogenolysis.
When the glycogen stores are exhausted, the muscle resorts to breaking down its protein fibers into their respective amino acids, with the glucogenic amino acids being transported to the liver where they are converted to glucose via gluconeogenesis; while the ketogenic amino acids are converted into ketone bodies.
This causes the muscle mass to decrease, a condition called muscle atrophy (commonly described as muscle wasting).
NIDDM and Damage to blood vessels
NIDDM also affects blood vessels. The blood vessel is internally lined by endothelial cells, and these cells do not need insulin to absorb glucose; which means that with the extremely high blood sugar concentrations, these cells absorbs lots of glucose.
The amount of glucose absorbed is much more than is required and because endothelial cells cannot store excess glucose as glycogen, and due to oxidative stress that creates lots of reactive oxygen species (RoS), the RoS facilitate the reaction between the excess glucose with cellular proteins to form glycoproteins, most of which are inserted in the cell membranes.
Where the endothelial cells attach to an underlying fibrous extracellular matrix (called the basement membrane), the glycoproteins accumulate and cause the basement membrane to become abnormally thick as well as grow weak.
This ultimately affects small blood vessels whose weak basement membranes allows proteins to leak, or vessels to burst under normal blood pressure so as to cause localized bleeding while cutting off blood supply to body areas beyond the burst blood vessels.
The collective term for these effects of diabetes on small blood vessels is diabetic microangiopathy.
In the kidneys, microangiopathy causes diabetic nephropathy, and in the retina of the eyes, its is called diabetic retinopathy and it can cause partial or total vision loss.
If blood supply to nerves is cut due to diabetic microangiopathy, then these nerves die alongside surrounding tissue, and this condition is called diabetic neuropathy.
Still, more tissue die to lack of blood supply till the skin ulcerates. Therefore, diabetic neuropathy results in diabetic ulcers, most of which are pressure ulcers which occur in the foot hence the designation diabetic foot.
Effects of diabetes on blood vessels also causes erectile dysfunction as inadequate blood is supplied to the penile tissue, and this blood volume cannot sustain an erection.
The aforementioned disease process of Type II diabetes mellitus and its complications highlight the need to manage this condition as early as possible. This can be done using Naavudi.
How does Naavudi Work?
The principal mode of action of Naavudi is enhancing the insulin sensitivity of cells located in adipose (fat) tissue, liver, and muscle tissue.
This optimizes the rate of glucose absorption into cells found in these tissues, and because these cells consume most of the glucose in the bloodstream, then the overall blood sugar concentration is set to fall down to within normal limits.
The active ingredients found in Naavudi cause these cells to have be sensitive to insulin. How each of these active ingredients works to improve insulin sensitivity or provides glucose support is explained below.
The power of Epicathecin
In a study published in 2001 in the Journal of Clinical and Experimental Pharmacology and Physiology, it was shown that Epicatechin has insulin-like properties.
This allows it to promote insulin sensitivity in erythrocytes by making the insulin receptors more capable, once insulin is bound, of activating the cellular cascade that inserts GLUT-4 on the cell membranes.
In a study published in April 2014 by the FASEB Journal, it was shown that Epicatechin reduces the basement membrane fibrosis caused by Type II DM, and it could improve the diabetic microangiopathy affecting heart tissue.
In 2015, Hindawi published a research from the Journal of Oxidative Medicine and Cellular Longevity, which showed that Epicatechin improves insulin sensitivity of cells and its ability to restore the cellular redox balance.
It does this by sequestering RoS (reactive oxygen species) which prevents glycoproteins from accumulating on the cell membranes of endothelial cells hence maintains the integrity of the endothelial layer of blood vessels.
This allows it to manage diabetic microangiopathy, while its ability to promote insulin sensitivity allows cells to take in glucose hence restoring the blood sugar level to normal limits. This also allows it to manage episodes of hyperglycemia.
Other vital components -- Vitamin C
Naavudi also contains vitamin C, a potent anti-oxidant that protects small blood vessels from being damaged by oxidative stress and RoS thereby preventing diabetic microangiopathy, or managing existing diabetic microangiopathy by restoring the vitality and patency of the endothelial layer.
It also reduces the oxidative stress that causes cells to develop insulin resistance, and when used concurrently with epicatechin, it greatly improves the insulin sensitivity of cells.
Another active ingredient is Fenugreek extracts which act on the digestive system to slow down the absorption of disaccharides and monosaccharides hence reducing the intensity of post-prandial hyperglycemia in diabetics.
Likewise, Fenugreek extract stimulate the beta-cells of the islets of Langerhans to produce insulin molecules above their normal production rates.
This leads to a higher insulin concentration in the blood which works the same way as insulin therapy, and hence can manage mild forms of IDDM.
The extracts of Java plum stimulate the beta-cells of the islets of Langerhans to produce insulin molecules above their normal production rates, as well as sensitizes the kidney to respond to hormones which cause it to eliminate large amount of dilute urine, hence reducing the intensity of glycosuria while eliminating fluid overload in the body. These extracts are also rich in Vitamin C.
Neem extracts promote glucose metabolism in the liver by making the hepatic cells highly sensitive to insulin, and this allows the liver to quickly rid the body of excess glucose during periods of spikes in blood sugar level.
The extracts of Kutki Root act on the digestive system to slow down the absorption of disaccharides and monosaccharides hence reducing the intensity of post-prandial hyperglycemia in diabetics. It also reduces craving for sugary (carbohydrate-rich) food.
The extracts of Holy Basil work by reducing the amounts of stress hormones, including cortisol, released by the body when the liver engages in gluconeogenesis.
These stress hormones causes muscle and fat tissue to break down their protein and fat so that they can be delivered to the liver as substrates for gluconeogenesis, which also causes rapid rise in blood glucose concentrations.
These extracts act on the adrenal and pancreatic glands to reduce their production of stress hormones.
Another active ingredient is gymnemic acid. In a study published in 2000, it was shown that gymnemic acid causes the pancreas to increase its rate of production of insulin while at the same time reducing the craving for sugary food.
It is for this reason that gymnemic acid is considered as an anti-obese, anti-hyperglycemia dietary supplement.
Indian Bay leaf
The extracts of Indian Bay leaf are known to contain powerful polyphenols which stimulate insulin production by the pancreas.
In a study published in 2009, it was shown that extract of Indian Bay leaf improve glucose metabolism by enhancing insulin production and making the cells more sensitive to insulin.
At the same time it is able to improve fat metabolism by promoting the breakdown of cholesterol and low density lipoprotein while increasing the concentration of good fat (that is high-density lipoprotein).
How to Achieve the Best Results using Naavudi
Naavudi is made by a leading producer of dietary supplements, CLE Holistic Health.
It comes in a plastic container holding 60 capsules, which the manufacturers recommends that they be taken in a daily dose of 2 capsules.
Still, the user should consult an expert health practitioners so as to know the right daily dosage.
Does Naavudi have Side Effects?
Naavudi is a dietary supplement made from natural plants. It can therefore be completely digested, absorbed, and metabolized the body the same the body does to normal food; and then be safely eliminated from the body.
Therefore, this glucose support product does not cause any side effects.
Are there Benefits of using Naavudi?
There are a myriad of benefits of using Naavudi, chief among them being the ability to control blood sugar concentration to healthy levels.
This dietary supplement also increases the rate of insulin production while making the cells more sensitive to insulin. This ultimately improves glucose metabolism by allowing more glucose to flow from the blood and into the cells.
Another benefit of Naavudi is that is reduces craving for sugary food hence acts as an anti-obese, anti-hyperglycemia product.
Equally, Naavudi has anti-stress benefits as it reduces the production of stress hormones in the body.